Review: Pemanfaatan Obat Herbal pada Penyakit Alzheimer dari Tiga Tanaman di Indonesia
Keywords:
Alzheimer, Centella asiatica, Curcuma longa, Moringa oleifera
Abstract
Alzheimer's disease is a disease in which brain damage is characterized by a decrease in attention, memory, and personality. Personality changes often occur when sufferers become less spontaneous, more apathetic, and withdrawn from their environment. The use of chemical drugs derived from the synthesis of natural drugs is approved for clinical use for Alzheimer's patients. Synthesis from natural materials is carried out because of the many chemical compounds contained in plants which have various biological and pharmacological effects. As for the use of natural medicines that are efficacious as antioxidants, anticoagulants, and anti-inflammatories, they are targets in the prevention of Alzheimer's disease where from these effects they can inhibit the acetylcholinesterase enzyme that plays a role in neurotransmitter damage. This journal review aims to maximize the use of natural medicines that have antioxidant effects from plants such as turmeric (Curcuma longa L.), gotu kola (Centella asiatica L.) and Kelor leaves (Moringa oleifera Lam.) so that these three plants are expected to have an effect. potential in the prevention of Alzheimer's disease which will be discussed extensively.
References
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[25]. Kitphati W, Wattanakamolkul K, Lomarat P, Phanthong P, Anantachoke N, Nukoolkam. 2012. Anticholinesterase of essential oil and their constituents from Thai medicinal plants purified and selular enzymes. Journal of Asian Association of Schools of Pharmacy. 1:58 – 60.
[26]. Wollen KA. 2010. Alzheimer disease: The pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners. Journal of Alternative Medicine. 15(3):223 – 224.
[27]. Shakil S, Khan R, Tabrez S, Alam Q, Jabir NR, Sulaiman MI. 2011. Interaction of human acetylcholinesterase with cyclophospamide; a molecular modeling and docking study, CNS & Neurological Disorders Drug Targeting. 10(7):845-848.
[28]. Aisen PS, Cummings J, Schneider LS. 2012. Symptomatic and nonamyloid/tau based pharmacologic treatment for alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2(3):1-21.
[29]. Ali R, Sheikh I, Jabir NR, Kamal, MA. 2012. Comparative Review of Decade’s and Neuroregeneration. 4(2):136-44.
[30]. Mashoque AR, Arokiasamy JT, Manivasagam T. 2018. Asiatic acid nullified aluminium toxicity in in vitro model of Alzheimer's disease. Frontiers in Bioscience (Elite Ed). 10:287-299.
[31]. Orhan IE. 2012. Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. Hindawi Publishing Corporation. 2:1-8
[32]. Hemamalini, Rao MS. 2013. Anti stress effect of Centella asiatica leaf extract on hippocampal neurons. International Journal of Pharmacology and Clinical Sciences. 2(1):25-32.
[33]. Deshpande PO, Mohan V, Thakurdesai P. 2015. Preclinical safety assesment of standardized extract of Centella asiatica (L.) Urban leaves. Journal toxicology int. 22(1): 10-20.
[34]. Jusril NA, Suhari AN, Bakar SIA, Saad WN, Adenan MI. 2020. Combining in silico and in vitro studies to evaluate the acetylcholinesterase inhibitory profile of different accessions and the biomarker triterpenes of Centella asiatica. Multidisciplinary Digital Publishing Institute Journal. 25(15): 3353.
[35]. Rao SB, Chetana M, and Devi PU, 2005. Centella asiatica treatment during postnatal period enhances learning and memory in mice. Physiology and Behavior. 86(4). 449–457.
[36]. Aminah S, Ramdhan T, Yanis M. 2015. Kandungan nutrisi dan sifat fungsional tanaman kelor (Moringa oleifera L.). jurnal buletin pertanian perkotaan. 5(2): 35-44.
[37]. Krisnadi D. Kelor Super Nutrisi.1st ed. Blora: Pusat Informasi dan Pengembangan Tanaman Kelor Indonesia. 2012, h 1-126.
[38]. Chivapat S, Sincharoenpokai P, Saktiyasuthorn N, Shuaprom A, thongsrirak P, Sakpetch A. 2011. Acute and Chronic Toxicity of Moringa oleifera Linn Leaves Extracts. Journal of Thai Veterinary Medicine. 41(4): 417-424.
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[40]. Sutangkala C, Wattanathorn J, Muchimapura S, Thukham W. 2013. Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia. Hindawi Publishing Corporation. 695936. h 9
[2]. Arwin L, Pratiwi J.N. 2020. Peran Neuroprotektor Astaxanthin dalam Pencegahan Penyakit Alzheimer. Jurnal Ilmu Keperawatan Jiwa. 3(1): 47-52.
[3]. Brookmeyer, R., Gray, S., Kawas, C. 1998. Projections of Alzheimer’s Disease in the United States and the Public Health Impact of Delaying Disease Onset. American Journal of Public Health. 88(9):1337-42.
[4]. Reubun, Y.T.A. 2020. Mekanisme Penghambatan Enzim Asetilkolinesterase pada Penyakit Alzheimer dari Ekstrak Herba Pegagan (Centella asiatica Linn.) dan Ekstrak Daun Kelor (Moringa oleifera Lam.) serta Kombinasinya. Thesis. Jakarta: Universitas Pancasila.
[5]. Wollen K.A. 2010. Alzheimer disease: The pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners. Journal of Alternative Medicine. 15(3): 223 – 224.
[6]. Aisen P.S, Cummings J, Schneider L.S. 2012. Symptomatic and nonamyloid/tau based pharmacologic treatment for alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2(3): 1-21.
[7]. Nisa K.M, Lisiswanti R. 2016. Faktor Risiko Demensia Alzheimer. Majority Journal. 5(4). 86-90.
[8]. Gendron T.F, Petrucelli L . 2009. The role of tau in neurodegeneration. Mol neurodegeneration. 4(13):1-19.
[9]. Zhang Y.W, Thompson R, Zhang H. 2011. APP Processing in Alzheimer’s Disease. Mol Brain. 4(3): 1-13.
[10]. Simanjuntak P. 2012. Review: Studi Kimia dan Farmakologi Tanaman Kunyit (Curcuma longa L.) sebagai Tumbuhan Obat Serbaguna. Jurnal Agrium. 17(2): 103-107.
[11]. Syahid S.F, Syukur C, Kiristina N.N, Pitono J. 2012. Adaptasi Delapan Nomor Harapan Kunyit (Curcuma domestica Vahl.) Toleran Nauran. Bul. Littro. 23(2):115-124.
[12]. Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee R.K. 2004. Turmeric and Curcumin; Biological Actions and Medicinal Applications. Current Science. 87(1):11.
[13]. Mishra S, Palanivelu K. 2008. The Effect of Curcumin (Turmeric) on Alzheimer’s Disease: An Overview. Ann Indian Acad Neurol. 11(3):13-19.
[14]. Kusbiantoro D, Purwaningrum Y. 2018. Pemanfaatan Kandungan Metabolit Sekunder pada Tanaman Kunyit dalam Mendukung Peningkatan Pendapatan Masyarakat. Jurnal kultivasi.17(1):544-549.
[15]. Majeed M, Badmaev V, Shivakumar U, Rajendran R. 1995. Curcuminoids; antioxidant phytonutrients. Nutri Science Publishers.
[16]. Giselle P.L., Teresa C, Fusheng Y, Walter B, Sally A.F, Greg M.C. 2001. The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse. J. Neurosci. 21(21):8370-8377.
[17]. Tsuyoshi H, Kenjiro O, Masahito Y. 2010. Curcumin and Alzheimer’s Disease. CNS Neuroscience & Therapeutics. 16:285-97.
[18]. John M.R, Sally A.F, Gregory M.C, Donna I.M, Jeffrey I.C. 2005. A Potential Role of the Curry Spice Curcumin in Alzheimer’s Disease. Current Alzheimer Research. 5(2):1-6.
[19]. Ataie A, Sabetkasaei M, Haghparast A, Hajizadeh M.A, Ataie R, Nasiraei M.S. 2010. An Investigation of the Neuroprotective Effects of Curcumin in A Model of Homocysteine – Induced Oxidative Stress in Rat’s Brain. DARU. 18(2):128-36.
[20]. Wijaya S, Arifin M. 2013. Analisis Potensi Curcumin Kunyit (Curcuma longa) sebagai Agen Neuroprotektor, Antiinflamasi, dan Antioksidan: Inovasi Pengembangan Terapi yang Efektif pada Penderita Alzheimer. Jurnal Ilmiah Mahasiswa Kedokteran Indonesia. 1(2):47-57.
[21]. Reddy, P. H., Manczak, M., & Mitchell, A. 2018. Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease. Journal of Alzheimer’s Disease. 61(3):843-866.
[22]. Valasani K.R, Sun Q, Hu G, Li J, Du F, Guo Y. 2014. Identification of Human ABAD Inhibitors for Rescuing Aβ- Mediated Mitochondrial Dysfunction. Curr Alzheimer Res. 11(2):128–136.
[23]. Sutardi, S. 2017. Kandungan Bahan Aktif Tanaman Pegagan dan Khasiatnya untuk Meningkatkan Sistem Imun Tubuh. Jurnal Penelitian dan Pengembangan Pertanian. 35:121.
[24]. Chivapat S, Sincharoenpokai P, Saktiyasuthorn N, Shuaprom A, thongsrirak P, Sakpetch A. 2011. Acute and Chronic Toxicity of Moringa oleifera Linn Leaves Extracts. Journal of Thai Veterinary Medicine. 41(4):417-424.
[25]. Kitphati W, Wattanakamolkul K, Lomarat P, Phanthong P, Anantachoke N, Nukoolkam. 2012. Anticholinesterase of essential oil and their constituents from Thai medicinal plants purified and selular enzymes. Journal of Asian Association of Schools of Pharmacy. 1:58 – 60.
[26]. Wollen KA. 2010. Alzheimer disease: The pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners. Journal of Alternative Medicine. 15(3):223 – 224.
[27]. Shakil S, Khan R, Tabrez S, Alam Q, Jabir NR, Sulaiman MI. 2011. Interaction of human acetylcholinesterase with cyclophospamide; a molecular modeling and docking study, CNS & Neurological Disorders Drug Targeting. 10(7):845-848.
[28]. Aisen PS, Cummings J, Schneider LS. 2012. Symptomatic and nonamyloid/tau based pharmacologic treatment for alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2(3):1-21.
[29]. Ali R, Sheikh I, Jabir NR, Kamal, MA. 2012. Comparative Review of Decade’s and Neuroregeneration. 4(2):136-44.
[30]. Mashoque AR, Arokiasamy JT, Manivasagam T. 2018. Asiatic acid nullified aluminium toxicity in in vitro model of Alzheimer's disease. Frontiers in Bioscience (Elite Ed). 10:287-299.
[31]. Orhan IE. 2012. Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. Hindawi Publishing Corporation. 2:1-8
[32]. Hemamalini, Rao MS. 2013. Anti stress effect of Centella asiatica leaf extract on hippocampal neurons. International Journal of Pharmacology and Clinical Sciences. 2(1):25-32.
[33]. Deshpande PO, Mohan V, Thakurdesai P. 2015. Preclinical safety assesment of standardized extract of Centella asiatica (L.) Urban leaves. Journal toxicology int. 22(1): 10-20.
[34]. Jusril NA, Suhari AN, Bakar SIA, Saad WN, Adenan MI. 2020. Combining in silico and in vitro studies to evaluate the acetylcholinesterase inhibitory profile of different accessions and the biomarker triterpenes of Centella asiatica. Multidisciplinary Digital Publishing Institute Journal. 25(15): 3353.
[35]. Rao SB, Chetana M, and Devi PU, 2005. Centella asiatica treatment during postnatal period enhances learning and memory in mice. Physiology and Behavior. 86(4). 449–457.
[36]. Aminah S, Ramdhan T, Yanis M. 2015. Kandungan nutrisi dan sifat fungsional tanaman kelor (Moringa oleifera L.). jurnal buletin pertanian perkotaan. 5(2): 35-44.
[37]. Krisnadi D. Kelor Super Nutrisi.1st ed. Blora: Pusat Informasi dan Pengembangan Tanaman Kelor Indonesia. 2012, h 1-126.
[38]. Chivapat S, Sincharoenpokai P, Saktiyasuthorn N, Shuaprom A, thongsrirak P, Sakpetch A. 2011. Acute and Chronic Toxicity of Moringa oleifera Linn Leaves Extracts. Journal of Thai Veterinary Medicine. 41(4): 417-424.
[39]. Nwidu LL, Elmorsy E, Aprioku JS, Siminialayi I, Carter WG. 2018. In vitro anticholinesterase and antioxidant activity of extracts of Moringa oleifera plants from River State, Niger Delta, Nigeria. Multidisciplinary Digital Publishing Institute Journal. 5. 71.
[40]. Sutangkala C, Wattanathorn J, Muchimapura S, Thukham W. 2013. Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia. Hindawi Publishing Corporation. 695936. h 9
Published
2023-02-20
How to Cite
Pangalila, A. (2023). Review: Pemanfaatan Obat Herbal pada Penyakit Alzheimer dari Tiga Tanaman di Indonesia. Jurnal Ayurveda Medistra, 4(2). https://doi.org/https://doi.org/10.51690/medistra-jurnal123.v4i2.70
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